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6,7,8 These proteins have emerged as critical molecular chaperones that facilitate folding, prevent aggregation, and stabilize proteins under stress

Group 1: Rats received 0.9% normal saline for 10 uninterrupted days followed by a single MTX dose (20 mg/kg, i.p)

I begin with the understanding that tinnitus is not a disease but a signal of a deeper imbalance within the body

Overall, we hope this review contributes to filling the gap between laboratories and clinics by clarifying the current understanding of how pain is produced in disc degeneration and inflammation, what kind of animal models we can use to study discogenic pain, and what strategies we are currently developing

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